Sun. Apr 27th, 2025

The Los Angeles Lakers visit the San Antonio Spurs in a Western Conference tilt on Wednesday. Los Angeles, coming off a Tuesday night los to the Mavericks, is 14-10 overall and 4-8 on the road this season. San Antonio is aiming to stop a 17-game losing streak, and the Spurs are 1-10 in home games at Frost Bank Center. The injury report for the Lakers is to be determined on the second night of a back-to-back, though Jarred Vanderbilt (back) and Gabe Vincent (knee) missed Tuesday’s game for Los Angeles. Charles Bassey (knee) is out for San Antonio.

Tipoff is at 8 p.m. ET in San Antonio. For this game, SportsLine consensus lists Los Angeles as the 2.5-point favorite, while the over/under, or total number of points Vegas thinks will be scored, is 227.5 in the latest Spurs vs. Lakers odds. Before making any Lakers vs. Spurs picks, you need to see the NBA predictions and betting advice from SportsLine’s advanced computer simulation model.

The SportsLine Projection Model simulates every NBA game 10,000 times and has returned well over $10,000 in profit for $100 players on its top-rated NBA picks over the past five-plus seasons. The model enters Week 8 of the 2023-24 NBA season on a sizzling 97-51 roll on all top-rated NBA picks dating back to last season, returning more than $4,000. Anyone following it has seen huge returns.

Now, the model has set its sights on Lakers vs. Spurs and just locked in its picks and NBA predictions. You can head to SportsLine now to see the model’s picks. Now, here are several NBA odds and betting lines for Spurs vs. Lakers:

Lakers vs. Spurs spread: Lakers -2.5
Lakers vs. Spurs over/under: 227.5 points
Lakers vs. Spurs money line: Lakers -141, Spurs +120
LAL: The Lakers are 0-4 against the spread with no rest this season
SA: The Spurs are 4-7 against the spread in home games
Lakers vs. Spurs picks: See picks at SportsLine

Why the Lakers can cover

The Lakers are capable of dominance on the defensive end. Los Angeles led the NBA In-Season Tournament in defensive rating (102.4), and the Lakers held opponents to 40.0% shooting and 31.7% from 3-point range in tournament games. Los Angeles is also firmly in the top 10 of the NBA in defensive efficiency for the full season, giving up fewer than 1.11 points per possession. The Lakers lead the league in free throw prevention, yielding fewer than 19 free throw attempts per game, and Los Angeles is in the top 10 of the league in opponent field goal percentage, opponent 2-point percentage and defensive rebound rate. 

Los Angeles also has advantages against a scuffling San Antonio offense. The Spurs are last in the league in offensive efficiency, scoring only 105.9 points per 100 possessions. San Antonio is also last in free throw creation, averaging 18.9 attempts per game, and the Spurs have bottom-five marks in field goal percentage, 3-point percentage and turnover avoidance. See which team to pick here.

Why the Spurs can cover

Victor Wembanyama keys the Spurs, and the No. 1 overall pick is starring in his first NBA season. Wembanyama is averaging 18.8 points per game, leading San Antonio, and he is in the top 10 of the NBA with 10.6 rebounds per contest. Wembanyama is also one of the league’s top rim protectors, averaging 2.8 blocked shots per game, and he is excelling with 19.3 points, 13.6 rebounds and 3.3 blocks per game over the last seven contests. San Antonio is in the top five of the NBA in averaging 28.8 assists per game, and the Spurs have the fewest shots blocked (3.7 per game) of any team in the league. 

The Lakers are also giving up more than 16 second-chance points per game, and Los Angeles is in the bottom third of the league in fast break points allowed. On the other end, the Lakers are dead-last in the NBA in second-chance points, with bottom-five marks in 3-pointers per game, 3-point accuracy, and offensive rebound rate. The Lakers are also committing nearly 15 turnovers per game. See which team to pick here.

How to make Lakers vs. Spurs picks

SportsLine’s model is leaning Over on the total, projecting 239 combined points. The model also says one side of the spread hits in 60% of simulations. You can only see the model’s picks at SportsLine.

So who wins Lakers vs. Spurs, and which side of the spread hits in 60% of simulations? Visit SportsLine now to see which side of the Lakers vs. Spready spread you need to jump on Wednesday, all from the model on a 97-51 roll on top-rated NBA picks, and find out.  

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